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secobarbital will lower the extent or effect of amiodarone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.secobarbital will reduce the extent or effect of conjugated estrogens, vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.If you are taking far too much SEDATIVE-HYPNOT